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Publisher: ACM
City: New York
ISBN: 978-1-4503-4824-9
Conference information: Proceedings of the 3rd International Conference on Biomedical and Bioinformatics Engineering

Abstract: A potentiometric sensor based on a molecularly imprinted polymer was fabricated for the detection of chloramphenicol (CAP), a broad spectrum antibiotic which is regulated by the government due to its toxicity at high doses, adverse effects and suspected carcinogenicity. The molecularly imprinted polymer for chloramphenicol (MIP-CAP) was prepared via precipitation polymerization with MAA as the functional monomer, EGDMA as cross-linker, and CAP as template. UV-Vis and FT-IR spectroscopy were used to confirm the synthesis of the MIP. The MIP has a binding capacity of 27.827 ± 1.267 mg CAP per gram MIP. Potentiometric measurements revealed a response of 57.85 mV/decade at the linear range of 10-5 to 10-3 M at the working pH 7.4. The limit of detection for the electrode was 7.639 x 10-6 M or 2.42 ppm. Response of the MIP and the MIP-modified electrode against structural analogues of CAP were also investigated.
Template and target information: Chloramphenicol, CAP