MIPs logo MIPdatabase      MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Liu J, Zhang Y, Jiang M, Tian LP, Sun SG, Zhao N, Zhao FL, Li YC
Article Title: Electrochemical microfluidic chip based on molecular imprinting technique applied for therapeutic drug monitoring.
Publication date: 2017
Journal: Biosensors and Bioelectronics
Volume: 91
Page numbers: 714-720.
DOI: 10.1016/j.bios.2017.01.037
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566317300374

Abstract: In this work, a novel electrochemical detection platform was established by integrating molecularly imprinting technique with microfluidic chip and applied for trace measurement of three therapeutic drugs. The chip foundation is acrylic panel with designed grooves. In the detection cell of the chip, a Pt wire is used as the counter electrode and reference electrode, and a Au-Ag alloy microwire (NPAMW) with 3D nanoporous surface modified with electro-polymerized molecularly imprinted polymer (MIP) film as the working electrode. Detailed characterization of the chip and the working electrode was performed, and the properties were explored by cyclic voltammetry and electrochemical impedance spectroscopy. Two methods, respectively based on electrochemical catalysis and MIP/gate effect were employed for detecting warfarin sodium by using the prepared chip. The linearity of electrochemical catalysis method was in the range of 5 x 10-6 - 4 x 10-4 M, which fails to meet clinical testing demand. By contrast, the linearity of gate effect was 2 x 10-11 - 4 x 10-9 M with remarkably low detection limit of 8 x 10-12 M (S/N=3), which is able to satisfy clinical assay. Then the system was applied for 24h monitoring of drug concentration in plasma after administration of warfarin sodium in rabbit, and the corresponding pharmacokinetic parameters were obtained. In addition, the microfluidic chip was successfully adopted to analyze cyclophosphamide and carbamazepine, implying its good versatile ability. It is expected that this novel electrochemical microfluidic chip can act as a promising format for point-of-care testing via monitoring different analytes sensitively and conveniently
Template and target information: warfarin sodium, cyclophosphamide, carbamazepine
Author keywords: Electrochemical microfluidic chip, molecularly imprinted polymer, Warfarin sodium, Nanoporous alloy microwire, therapeutic drug monitoring


  mipdatabase.com logo special offer joke shirt  Lab Honey Periodic table mug  HE-MAN polymer chemistry shirt

Molecules Special Issue call     Sensors Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon