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Reference type: Journal
Authors: Huang BT, Xiao LL, Dong HF, Zhang XJ, Gan W, Mahboob S, Al-Ghanim KA, Yuan QH, Li YC
Article Title: Electrochemical sensing platform based on molecularly imprinted polymer decorated N,S co-doped activated graphene for ultrasensitive and selective determination of cyclophosphamide.
Publication date: 2017
Journal: Talanta
Volume: 164
Page numbers: 601-607.
DOI: 10.1016/j.talanta.2016.11.009
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0039914016308815

Abstract: A novel electrochemical sensor has been facilely fabricated by applying composite elements consisting of nitrogen and sulfur co-doped activated graphene (N,S-AGR) and molecularly imprinted polymer (MIP). N,S-AGR was synthesized by one-pot pyrogenation of a mixture of thiourea, KOH and graphene oxide, which was introduced to improve electron transfer capability and surface area of the electrode, while the electro-polymerized MIP layer afforded simultaneous recognition and quantification of cyclophosphamide (CPA) by utilizing Fe(CN)63-/4- as probe to indicate electrical signals. Under the optimal conditions, a calibration curve of current shift versus concentration of CPA was got in the range of 8 x 10-12 - 8 x 10-7 mol L-1, and the developed sensor gave a remarkably low detection limit (LOD) of 3.4 x 10-12 mol L-1 (S/N=3). Moreover, the as-prepared sensor illustrated other good merits like stability and selectivity, and played a role in real-time therapeutic drug monitoring after CPA administration in rabbit
Template and target information: cyclophosphamide, CPA
Author keywords: Electrochemical sensor, Cyclophosphamide, Nitrogen and sulfur co-doped activated grapheme, Drug monitoring


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