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Abstract: A molecularly imprinted polymer (MIP) film for the determination of phenobarbital was fabricated to a glassy carbon electrode using methacrylic acid as functional monomer,ethylene glycol maleic rosinate acrylate as the cross linking agent by the free radical polymerization method. The optimum experimental conditions were explored. Under the optimum experimental conditions,the response performances of the sensor for phenobarbital recognition were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The results indicate that the peak current of sensor shows a linear dependence on the phenobarbital concentration in the range of 3. 0 x 10-6 ~ 1. 0 x 10-4 mol/L. (Linear regression coefficient = 0. 9976) with the detection limit (S/N = 3) of 5. 4 x 10-5 mmol / L. This imprinted polymer (MIP) film electrode also displays good selectivity and reproducibility and stability. The prepared sensor was successfully applied to the determination of phenobarbital in phenobarbital tablet samples with recoveries ranging from 91.5% to 107.5%.
Template and target information: phenobarbital
Author keywords: phenobarbital, Ethylene glycol maleic acrylate, molecularly imprinted polymer, Electrochemical sensor