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Reference type: Journal
Authors: Kioomars S, Heidari S, Malaekeh-Nikouei B, Shayani Rad M, Khameneh B, Mohajeri SA
Article Title: Ciprofloxacin-imprinted hydrogels for drug sustained release in aqueous media.
Publication date: 2017
Journal: Pharmaceutical Development and Technology
Volume: 22
Issue: (1)
Page numbers: 122-129.
DOI: 10.1080/10837450.2016.1230131

Abstract: In this study several ciprofloxacin (CFX) imprinted and non-imprinted hydrogels were prepared and evaluated as ocular drug delivery systems in aqueous media. 2-Hydroxyethyl methacrylate (HEMA) was used as a solvent and backbone monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker, methacrylic acid (MAA) as a functional monomer and CFX as the template molecule. CFX-imprinted hydrogels (MIPs) were prepared applying different CFX:MAA molar ratios (1:16, 1:20 and 1:32) in feed composition of monomer solutions. Thermal polymerization was applied and hydrogels were synthesized in a polypropylene mold (0.4 mm thickness). Swelling and binding properties of hydrogels were evaluated in water. Release profile of the MIPs was evaluated in NaCl (0.9%) and artificial tears. The data showed that enhancing the MAA concentration, as a co-monomer, and using molecular imprinting improved binding properties of the synthesized hydrogels. The optimized MIPs with 400 mM MAA and CFX: MAA molar ratio of 1:20 and 1:16 showed the greatest affinity for CFX and the highest ability to control drug release. In vitro antibacterial activity of hydrogels was studied and demonstrated the effect of CFX-loaded hydrogels against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus) isolated from patients' eyes. This study indicated antibacterial efficacy of CFX-loaded MIP hydrogels
Template and target information: ciprofloxacin, CFX
Author keywords: Ciprofloxacin, hydrogels, molecular imprinting, ocular drug delivery systems


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