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Reference type: Journal
Authors: Xie YF, Zhao MY, Hu Q, Cheng YL, Guo YH, Qian H, Yao WR
Article Title: Selective detection of chloramphenicol in milk based on a molecularly imprinted polymer-surface-enhanced Raman spectroscopic nanosensor.
Publication date: 2017
Journal: Journal of Raman Spectroscopy
Volume: 48
Issue: (2)
Page numbers: 204-210.
DOI: 10.1002/jrs.5034

Abstract: In this study, a novel hybrid molecularly imprinted polymer (MIP) with a surface-enhanced Raman spectroscopy (SERS) sensor was proposed for the detection of chloramphenicol in milk. The MIP was prepared by precipitation polymerization, and the template molecule was extracted by ultrasonic wave. The polymer was placed in a sodium citrate reduction reaction to prepare the chloramphenicol-MIP-Au substrate. The optimal detection conditions were carried out in a mixed solution of methanol and water (1:9). The sensor can be used to detect chloramphenicol in milk samples with a detection limit of 0.1 μg/ml. The chloramphenicol-MIP-Au substrate served not only as an enrichment medium but also as an enhancement substrate base for SERS detection. Experimental results showed that the MIP hybrid as a SERS platform owned potential for simplifying the detection step and highly selective detection of chloramphenicol in milk. Copyright 2016 John Wiley & Sons, Ltd
Template and target information: chloramphenicol
Author keywords: molecularly imprinted polymers (MIP), SERS, chloramphenicol, Nanosensor, detection


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