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Book title: Polymeric Reagents and Catalysts
Editors: Ford WT
Publisher: The American Chemical Society
City: Washington DC
Series title: ACS Symposium Series
Volume number: 308

Abstract: This is a review on attempts to produce specific binding sites in synthetic polymers analogous to those of biological receptors or natural enzymes. For this goal an imprinting procedure was used with the aid of templates in crosslinked polymers. Suitable polymerizable binding groups were bound to a template molecule. This was copolymerized into highly crosslinked polymers. After the removal of the templates the remaining cavities possessed a shape and an arrangement of their functional groups corresponding that of the template. Applications of these polymers for optical resolution of racemates, for selective metal ion binding, and for stereoselective reactions are reviewed. The optimization of the polymer structure is described and the origin of the memory effect discussed. Similar imprints can be obtained on surfaces of silica.