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Reference type: Journal
Authors: Xu ZF, Deng PH, Li JH, Xu L, Tang SP
Article Title: Molecularly imprinted fluorescent probe based on FRET for selective and sensitive detection of doxorubicin.
Publication date: 2017
Journal: Materials Science and Engineering: B
Volume: 218
Page numbers: 31-39.
DOI: 10.1016/j.mseb.2017.02.005
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0921510717300338

Abstract: In this work, a new type of fluorescent probe for detection of doxorubicin has been constructed by the combined use of fluorescence resonance energy transfer (FRET) technology and molecular imprinting technique (MIT). Using doxorubicin as the template, the molecularly imprinted polymer thin layer was fabricated on the surfaces of carbon dot (CD) modified silica by sol-gel polymerization. The excitation energy of the fluorescent donor (CDs) could be transferred to the fluorescent acceptor (doxorubicin). The FRET based fluorescent probe demonstrated high sensitivity and selectivity for doxorubicin. The detection limit was 13.8 nM. The fluorescent probe was successfully applied for detecting doxorubicin in doxorubicin-spiked plasmas with a recovery of 96.8-103.8%, a relative standard deviation (RSD) of 1.3-2.8%. The strategy for construction of FRET-based molecularly imprinted materials developed in this work is very promising for analytical applications
Template and target information: doxorubicin
Author keywords: doxorubicin, molecular imprinting, FRET, molecular recognition, Fluorescent carbon dots

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