MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Lai SZ, Tang ST, Xie JQ, Cai CQ, Chen XM, Chen CY
Article Title: Highly efficient chiral separation of amlodipine enantiomers via triple recognition hollow fiber membrane extraction.
Publication date: 2017
Journal: Journal of Chromatography A
Volume: 1490
Page numbers: 63-73.
DOI: 10.1016/j.chroma.2017.02.018
Alternative URL: http://www.sciencedirect.com/science/article/pii/S002196731730242X

Abstract: In this study, a triple recognition chiral extraction process has been developed to separate (S)-amlodipine from racemic raw medicine, based on the combination of molecularly imprinted hollow fiber membrane and cross-flow biphasic recognition extraction. The chiral separation process was operated in a dismountable hollow fiber module coated with molecularly imprinted polymer, and the cross-flow extraction was applied with d-tartaric acid in feed phase and sulfobutyl ether-β-cyclodextrin in stripping phase. The synergistic effect of molecularly imprinted polymer and dual chiral additives was investigated, and excellent enantioseparation ability with a selectivity factor of 1.98 was obtained. Mathematical model of S/R = 0.598e0.150NTU for racemic amlodipine separation by molecularly imprinted hollow fiber membrane extraction was established. The optical purity for amlodipine is up to 90% when 4 hollow fiber membrane modules of 25 cm in length in series are used. The triple recognition process strongly enhanced the separation selectivity; therefore it may bring about the potentially application for large-scale production of pure enantiomeric compound
Template and target information: (S)-amlodipine, amlopidine
Author keywords: Amlodipine, enantioseparation, Hollow fiber, molecularly imprinted membrane, Triple recognition

  Periodic table Teacher shirt  PhD Chemist peptide mug  Gravity waves shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner