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Reference type: Journal
Authors: Lai SZ, Tang ST, Xie JQ, Cai CQ, Chen XM, Chen CY
Article Title: Highly efficient chiral separation of amlodipine enantiomers via triple recognition hollow fiber membrane extraction.
Publication date: 2017
Journal: Journal of Chromatography A
Volume: 1490
Page numbers: 63-73.
DOI: 10.1016/j.chroma.2017.02.018
Alternative URL: http://www.sciencedirect.com/science/article/pii/S002196731730242X

Abstract: In this study, a triple recognition chiral extraction process has been developed to separate (S)-amlodipine from racemic raw medicine, based on the combination of molecularly imprinted hollow fiber membrane and cross-flow biphasic recognition extraction. The chiral separation process was operated in a dismountable hollow fiber module coated with molecularly imprinted polymer, and the cross-flow extraction was applied with d-tartaric acid in feed phase and sulfobutyl ether-β-cyclodextrin in stripping phase. The synergistic effect of molecularly imprinted polymer and dual chiral additives was investigated, and excellent enantioseparation ability with a selectivity factor of 1.98 was obtained. Mathematical model of S/R = 0.598e0.150NTU for racemic amlodipine separation by molecularly imprinted hollow fiber membrane extraction was established. The optical purity for amlodipine is up to 90% when 4 hollow fiber membrane modules of 25 cm in length in series are used. The triple recognition process strongly enhanced the separation selectivity; therefore it may bring about the potentially application for large-scale production of pure enantiomeric compound
Template and target information: (S)-amlodipine, amlopidine
Author keywords: Amlodipine, enantioseparation, Hollow fiber, molecularly imprinted membrane, Triple recognition


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