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Reference type: Journal
Authors: Khan S, Miguel EM, de Souza CF, da Silva AR, Aucélio RQ
Article Title: Thioglycolic acid-CdTe quantum dots sensing and molecularly imprinted polymer based solid phase extraction for the determination of kanamycin in milk, vaccine and stream water samples.
Publication date: 2017
Journal: Sensors and Actuators B: Chemical
Volume: 246
Page numbers: 444-454.
DOI: 10.1016/j.snb.2017.02.117
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0925400517303441

Abstract: Kanamycin is an antibiotic from the aminoglycoside class used to treat a myriad of infections. Aminoglycosides enhanced the photoluminescence of the thioglycolic acid modified CdTe quantum dots (TGA-CdTe QDs) following a Langmuir binding isotherm model. Binding constants were calculated indicating strong interactions between surface of nanoparticles and aminoglycosides. For kanamycin, the equilibrium binding constant was of 5.6 x 10^7 L mol-1. Based on this, a sensitive and selective method was developed for kanamycin determination based on the enhanced photoluminescence of TGA-CdTe QDs. Solid phase extraction with a new molecularly imprinted polymer, made using kanamycin as a template, provided high selectivity towards aminoglycosides. Under adjusted conditions, the two orders of magnitude analytical curve (linearized Langmuir binding isotherm) was constructed from 1.4 x 10-8 mol L-1 (limit of quantification) to 1.6 x 10-6 mol L-1 (8.1-92.8 ng mL-1) of kanamycin sulphate. The proposed procedure was tested for the determination of kanamycin in milk and yellow fever vaccine with recoveries between 86.6 and 93.7%. In addition, the kanamycin effect on TGA-CdTe QDs was also demonstrated under capillary electrophoresis regime, indicating another possibility for selective sensing
Template and target information: kanamycin
Author keywords: Kanamycin, Aminoglycosides, CdTe Quantum dots, molecularly imprinted polymer, milk

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