MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Wulff G, Minarik M
Article Title: Template imprinted polymers for HPLC separation of racemates.
Publication date: 1990
Journal: Journal of Liquid Chromatography
Volume: 13
Issue: (15)
Page numbers: 2987-3000.
DOI: 10.1080/01483919008049082
Alternative URL: http://www.informaworld.com/10.1080/01483919008049082

Abstract: A novel approach to the separation of enantiomers using polymeric sorbents imprinted with optically active template molecules has been examined for use in HPLC. The racemate of the template molecule can be separated whereby covalent interactions are responsible for retardation in the chromatographic process. This covalent interaction governs the overall kinetics of the separation. Increasing the reaction rate of this binding reaction by optimizing the experimental conditions improves the separation considerably. The template form of the enantioraeric mixture is thus strongly retarded and separated from the non-template form. A further substantial improvement of the chromatographic pattern is obtained by and it is remarkable that the racemic resolution of mannose n this polymer is possible although the template is different. This finding offers the possibility of the racemic resolution of underivated sugar which s not possible by other methods at the present time. It gives also an insight into the separation mechanism of template imprinted polymers. It encourages us to postulate that more than the precise shape of the cavities, the spatial arrangement of the interactive groups within the cavities plays a predominant role in the enantioselective separation mechanism of this sorbent type (13).


  Argon periodic table greetings card  Scientist peptide mug  I shop perodically customisable tote bag

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner