Authors: Bertolla M
, Cenci L
, Anesi A
, Ambrosi E
, Tagliaro F
, Vanzetti L
, Guella G
, Bossi AM
Solvent-Responsive Molecularly Imprinted Nanogels for Targeted Protein Analysis in MALDI-TOF Mass Spectrometry.
Publication date: 2017
Journal: ACS Applied Materials & Interfaces
Abstract: Molecular imprinted poly(acrylamido)-derivative nanogels have shown their selectivity to bind the protein human serum transferrin (HTR) and also showed their capability for instantaneous solvent-induced modification upon the addition of acetonitrile. Integrated to matrix-assisted laser desorption/ionization time-of-flight mass analysis the HTR-imprinted solvent-responsive nanogels permitted the determination of HTR straight from serum and offered novel perspectives in targeted protein analysis
Template and target information: protein, human serum transferrin, HTR
Author keywords: MALDI, mass spectrometry, Molecularly imprinted polymers, Nanogels, polyacrylamide, responsive material, serum transferrin, targeted protein analysis
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