Abstract: In this study we describe cephradine templated molecularly imprinted polymers (MIPs) prepared by bulk polymerization of 4-vinyl pyridine and ethylene glycol dimethacrylate (EGDMA). The nonimprinted and cephradine imprinted polymer matrix was fully characterized by Fourier transform infrared spectroscopy (FT-IR) and UV-visible spectroscopy. Binding performance of MIP was evaluated through multiple parameters naming (i) the effect of time, (ii) pH and (iii) amount. Furthermore, cephradine titration showed a linear response in the wide range of 10-100 μM with MIP, and the rebinding study of the drug infers that the molecular induction from this specific imprint to the cephradine template is larger and highly selective. The binding capability of this newly synthesized MIP was calculated to be 5 μg/3 mg in aqueous solution. Hence this probe provides a robust and economical tool to detect and remove cephradine in environmental samples.
Template and target information: cephradine
Author keywords: cephradine, MIP, quantification, Recognition, water treatment