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Reference type: Journal
Authors: Chen L, Lian HT, Sun XY, Liu B
Article Title: Sensitive detection of L-5-hydroxytryptophan based on molecularly imprinted polymers with graphene amplification.
Publication date: 2017
Journal: Analytical Biochemistry
Volume: 526
Page numbers: 58-65.
DOI: 10.1016/j.ab.2017.03.017
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0003269717301331

Abstract: A novel electrochemical sensor was presented for the determination of L-5-hydroxytryptophan (L-5-HTP) based on a graphene-chitosan molecularly imprinted film modified on the surface of glassy carbon electrode (GR-MIP/GCE). The morphology and composition of the imprinted film were observed in field emission scanning electron microscopy (FESEM), raman spectroscopy and fourier transform infrared (FTIR). The properties of the sensor were evaluated by electrochemical techniques. Under the optimal conditions, the peak currents of L-5-HIP were found to be linear in the concentration range of 0.05-7.0 μM, while the sensor also exhibited great features such as low detection limit of 6.0 nM (S/N = 3), superb selectivity against the structural analogues, good antidisturbance ability among coexisting components, excellent repeatability and stability. Moreover, the proposed method had been applied to the detection of L-5-HTP in human blood serum with a satisfactory recoveries ranging from 90.6% to 105.6%
Template and target information: L-5-hydroxytryptophan, L-5-HTP
Author keywords: L-5-Hydroxytryptophan, Graphene, molecularly imprinting, chitosan


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