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Reference type: Journal
Authors: Shen M, Rusling JF, Dixit CK
Article Title: Site-selective orientated immobilization of antibodies and conjugates for immunodiagnostics development.
Publication date: 2017
Journal: Methods
Volume: 116
Page numbers: 95-111.
DOI: 10.1016/j.ymeth.2016.11.010
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1046202316304522

Abstract: Immobilized antibody systems are the key to develop efficient diagnostics and separations tools. In the last decade, developments in the field of biomolecular engineering and crosslinker chemistry have greatly influenced the development of this field. With all these new approaches at our disposal, several new immobilization methods have been created to address the main challenges associated with immobilized antibodies. Few of these challenges that we have discussed in this review are mainly associated to the site-specific immobilization, appropriate orientation, and activity retention. We have discussed the effect of antibody immobilization approaches on the parameters on the performance of an immunoassay
Template and target information: Review - immunodiagnostics
Author keywords: Site-selective, Site-specific, orientation, immobilization, antibody, Antibody fragments, click chemistry, Affinity tags, Protein A, Nucleotide binding protein, Metal binding protein, Staudinger ligation, cycloaddition, Antibody-binding protein, Physical adsorption, Diagnostics, Therapeutics, separation


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