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Reference type: Journal
Authors: Chen KC, He R, Luo XY, Qin PZ, Tan L, Tang YW, Yang ZC
Article Title: A fluorescent glycosyl-imprinted polymer for pH and temperature regulated sensing of target glycopeptide antibiotic.
Publication date: 2017
Journal: Biosensors and Bioelectronics
Volume: 94
Page numbers: 609-615.
DOI: 10.1016/j.bios.2017.03.059
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566317302245

Abstract: This paper demonstrates a new strategy for developing a fluorescent glycosyl-imprinted polymer for pH and temperature regulated sensing of target glycopeptide antibiotic. The technique provides amino modified Mn-doped ZnS QDs as fluorescent supports, 4-vinylphenylbronic acid as a covalent monomer, N-isopropyl acrylamide as a thermo-responsive monomer in combination with acrylamide as a non-covalent monomer, and glycosyl moiety of a glycopeptide antibiotic as a template to produce fluorescent molecularly imprinted polymer (FMIP) in aqueous solution. The FMIP can alter its functional moieties and structure with pH and temperature stimulation. This allows recognition of target molecules through control of pH and temperature. The fluorescence intensity of the FMIP was enhanced gradually as the concentration of telavancin increased, and showed selective recognition toward the target glycopeptide antibiotic preferentially among other antibiotics. Using the FMIP as a sensing material, good linear correlations were obtained over the concentration range of 3.0-300.0 μg/L and with a low limit of detection of 1.0 μg/L. The analysis results of telavancin in real samples were consistent with that obtained by liquid chromatography tandem mass spectrometry
Template and target information: glycosyl, glycopeptide antibiotic, telavancin
Author keywords: molecular imprinting, Quantum dots, Fluorescence probes, Glycopeptide antibiotics

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