MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Hao J, Jiang J, Shao RT, Ding XY, Shi N, Lu Y
Article Title: Determination of Eleven β-Blocker Residues in Animal Derived Foods by Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry with Molecularly Imprinted Solid Phase Extraction.
Publication date: 2016
Journal: Journal of Instrumental Analysis
Volume: 35
Issue: (10)
Page numbers: 1278-1282.
Alternative URL: http://fxcsxb.com/ch/reader/view_abstract.aspx?file_no=20161010&flag=1

Abstract: A molecularly imprinted solid phase extraction coupled with ultra high performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method was developed for the determination of eleven beta blocker residues in animal derived foods. The sample was enzymed with β-glucuronidase/aryl sulfatase. The supernatant fraction was adjusted to the optimal pH value,and then extracted with isopropanol-ethyl acetate (5:5,by volume). The organic solvent was first evaporated to dryness, and then redissolved, finally purified by molecularly imprinted solid phase extraction. The analyte was separated with a BEH C18 column by gradient elution using methanol-5 mmol/L ammonium acetate (containing 0.1% formic acid) as mobile phase,and detected by MS under ESI+ ionization and multiple reactions monitoring mode. The quantification of the analytes was performed by the matrix standard addition method. The limits of detection and limits of quantitation were in the ranges of 0.02-0.1 μg/kg and 0.05-0.25 μg/kg,respectively. The calibration curves of 11 β-blockers were linear in the range of 0.05-10 μg/kg,with correlation coefficients not less than 0.991. Under three spiked levels, the average recoveries of the analytes in pork and liver were 73.2%-108.3% and 70.2%-98.2%, respectively, with relative standard deviations of 1.3%-9.5% and 3.7%-9.8%, respectively. The method is rapid, sensitive and precise, and is suitable for the determination of β-blocker multi residues in animal derived foods.
Template and target information: β-blockers
Author keywords: molecularly imprinted solid phase extraction, liquid chromatography-tandem mass spectrometry (LC-MS, MS), β-Blocker, Residue determination

  Eat, sleep, imprint, repeat mug  SMI logo mug  Woman of proper-tea mug in red

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner