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Reference type: Journal
Authors: Rossetti C, Switnicka-Plak MA, Halvorsen TG, Cormack PAG, Sellergren B, Reubsaet L
Article Title: Automated Protein Biomarker Analysis: on-line extraction of clinical samples by Molecularly Imprinted Polymers.
Publication date: 2017
Journal: Scientific Reports
Volume: 7
Page numbers: ArticleNo44298.
DOI: 10.1038/srep44298

Abstract: Robust biomarker quantification is essential for the accurate diagnosis of diseases and is of great value in cancer management. In this paper, an innovative diagnostic platform is presented which provides automated molecularly imprinted solid-phase extraction (MISPE) followed by liquid chromatography-mass spectrometry (LC-MS) for biomarker determination using ProGastrin Releasing Peptide (ProGRP), a highly sensitive biomarker for Small Cell Lung Cancer, as a model. Molecularly imprinted polymer microspheres were synthesized by precipitation polymerization and analytical optimization of the most promising material led to the development of an automated quantification method for ProGRP. The method enabled analysis of patient serum samples with elevated ProGRP levels. Particularly low sample volumes were permitted using the automated extraction within a method which was time-efficient, thereby demonstrating the potential of such a strategy in a clinical setting
Template and target information: peptide, ProGastrin Releasing Peptide, ProGRP, cancer biomarker

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