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Abstract: The purpose of this study was to formulate an antioxidant topical cosmetic molecularly imprinted system for skin aging and was to evaluate the formulation in vivo on human volunteers. Molecular imprinted cyclodextrins (CDs) were prepared by cross-linking cyclodextrins (CD) in the presence of a vitamin E (VE) as template molecule. Characterization studies were performed on molecularly imprinted polymers (MIP) and non-imprinted polymers (NIP). Antioxidant effects of formulations prepared were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) test. In vivo skin measurements were done on human volunteers including sebum, moisture, pH, net elasticity and roughness parameters. It was seen that temperature increase influced the particle size of imprinted polymers. It was determined that MIP systems have an antioxidant effect. Formulations showed a positive effect on skin roughness parameter was determined statistically (p £ 0.01). The preparation method of MIP is simple and quick and it will provide opportunities in future on specific cosmetic formulations.
Template and target information: α-tocopherol, vitamin E, VE
Author keywords: molecularly imprinted polymer, vitamin E, β-cyclodextrin, cosmetic application, in vivo skin measurement