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Reference type: Journal
Authors: Yano K, Karube I
Article Title: Development of artificial host polymers which mimick biochemical interactions.
Publication date: 1997
Journal: Abstracts of Papers of the American Chemical Society
Volume: 213
Issue: (IEC)
Page numbers: 114.

Abstract: Separations using molecularly imprinted polymers (MIPs) which mimic biological interactions are reported. Multiple hydrogen bonding interactions between nucleotide bases play a crucial role in stabilizing the structure of double-stranded DNA. A novel functional monomer designed to form multiple hydrogen bonds with barbiturate templates has been synthesized and used for molecular imprinting. Liquid chromatographic analysis shows that a cyclobarbital-imprinted polymer possesses a distinct preference for the template molecule. Another example which mimics the interactions between peptide bonds in -helical or -sheet domains of proteins is introduced. A MIP which utilizes a L-valine derivative as a functional monomer is shown to exhibit stereoselectivity for a number of dipeptides


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