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Abstract: Through precipitation polymerization, a novel water-compatible and positive thermo-responsive molecularly imprinted nanoparticle (MINP) was successfully synthesized in aqueous solution using acrylamide (AAm) and 2-acrylamide-2-methyl propanesulfonic acid (AMPS) as functional monomer, N,N'-methylenebis(acrylamide) (MBA) as cross-linker, and levofloxacin (LOFL) as template. The MINP was composed of LOFL imprinted matrix, which showed positively thermo-responsive interpolymer interaction between poly(AAm) and poly(AMPS). To obtain MINP with excellent molecular recognition ability, the composition and ratio of recipe were optimized in detail. The resultant MINP was characterized by transmission electron microscope, thermogravimetric analysis, nitrogen adsorption-desorption isotherms, and Fourier transform infrared spectra. The binding behavior demonstrated the zipper-like switchable molecular recognition ability for temperature. The low temperature could stabilize interpolymer interaction between poly(AAm) and poly(AMPS), thus the MINP demonstrated poor molecular recognition ability at 20 °C. In contrast, the high temperature resulted to the dissociation of poly(AAm)-poly(AMPS) complexes and promote the mass transfer of target in and out the MINP. Therefore, the MINP exhibited significant molecular recognition ability at 40 °C. In contrast to previously inverse thermo-responsive nanomaterials, this zipper-like thermo-responsive MINP is unique and has prospects in extensive application
Template and target information: levofloxacin, LOFL
Author keywords: molecularly imprinted polymer, Thermo-responsive, nanoparticles, molecular recognition, water compatibility