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Reference type: Journal
Authors: Lulinski P
Article Title: Molecularly imprinted polymers based drug delivery devices: a way to application in modern pharmacotherapy. A review.
Publication date: 2017
Journal: Materials Science and Engineering: C
Volume: 76
Page numbers: 1344-1353.
DOI: 10.1016/j.msec.2017.02.138
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0928493116318872

Abstract: This review presents the current status of molecularly imprinted polymers (MIPs) for drug delivery, in particular the studies that focus on biocompatibility, cytotoxicity, and in vitro or in vivo behavior of MIPs. It also shows the limitations that hamper the introduction of MIPs to pharmacotherapy and prevent this class of polymers from commercialization. MIPs are promising materials in the construction of drug delivery devices because they can provide improved delivery profiles or longer release times and deliver the drugs in the feedback regulated way, which is extremely important in modern pharmacotherapy. Here, a brief overview of the imprinting process and a concise description of drug release mechanisms from the imprinted materials will be presented followed by the discussion of potential MIP drug delivery devices for ocular, dermal, intravenous and oral routes of administration. Finally, future prospects for imprinted drug delivery forms will be outlined
Template and target information: Review - MIPs in drug delivery
Author keywords: Molecularly imprinted polymers, drug delivery, Pharmacotherapy, Sustained, controlled release


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