MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Paul PK, Treetong A, Suedee R
Article Title: Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system.
Publication date: 2017
Journal: Acta Pharmaceutica
Volume: 67
Page numbers: 149-168.
DOI: 10.1515/acph-2017-0020
Alternative URL: https://www.researchgate.net/publication/318056053_Biomimetic_insulin-imprinted_polymer_nanoparticles_as_a_potential_oral_drug_delivery_system

Abstract: In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7.4 than at pH 1.2. In vivo studies on diabetic Wistar rats showed that the fast onset within 2 h is similar to subcutaneous injection with a maximum at 4 h, giving an engaged function responsible for the duration of glucose reduction for up to 24 h. These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery.
Template and target information: insulin
Author keywords: Molecularly imprinted polymers, Insulin, nanoparticles, islet cells, oral drug delivery


  Mister Benzene Drinkies frosty mug  Chemistry peptide mug  Beach bunny periodic table shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner