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Reference type: Journal
Authors: Paul PK, Treetong A, Suedee R
Article Title: Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system.
Publication date: 2017
Journal: Acta Pharmaceutica
Volume: 67
Page numbers: 149-168.
DOI: 10.1515/acph-2017-0020
Alternative URL: https://www.researchgate.net/publication/318056053_Biomimetic_insulin-imprinted_polymer_nanoparticles_as_a_potential_oral_drug_delivery_system

Abstract: In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7.4 than at pH 1.2. In vivo studies on diabetic Wistar rats showed that the fast onset within 2 h is similar to subcutaneous injection with a maximum at 4 h, giving an engaged function responsible for the duration of glucose reduction for up to 24 h. These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery.
Template and target information: insulin
Author keywords: Molecularly imprinted polymers, Insulin, nanoparticles, islet cells, oral drug delivery

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