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Reference type: Journal
Authors: Liu Y, Shen T, Hu L, Gong H, Chen CY, Chen XM, Cai CQ
Article Title: Development of a thermosensitive molecularly imprinted polymer resonance light scattering sensor for rapid and highly selective detection of hepatitis A virus in vitro.
Publication date: 2017
Journal: Sensors and Actuators B: Chemical
Volume: 253
Page numbers: 1188-1193.
DOI: 10.1016/j.snb.2017.07.166
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0925400517313801

Abstract: In this study, a thermosensitive imprinted polymer coating SiO2 was developed for a resonance light scattering (RLS) thermosensitive virus-affinity sensor, which exhibited high selectivity for virus monitoring. In this sensor, N-isopropylacrylamide was a temperature-sensitive element. The recognition performance of the nanosensor for viruses was regulated by temperature control for the specific capture of the target virus at 40 C, resulting in the increase of RLS intensity and its release at 20 C. Moreover, the RLS intensity of the nanosensor significantly increased within 30 min. Accordingly, a very good detection limit of 1.1 pmol L-1 was obtained. The nanosensor was successfully used to detect the additional hepatitis A virus from a dilution of human serum, and recoveries in the range of 90.8% to 108.3% were attained at three spiking levels of viruses. Overall, this study addressed the problems of high nonspecific adsorption and long duration of detection process. Furthermore, a facile, rapid, and efficient tool for virus detection was provided
Template and target information: viruses, hepatitis A virus
Author keywords: Thermo-sensitive, Virus molecularly imprinted polymers, Resonance light scattering, Specific detection

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