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Reference type: Journal
Authors: El-Beqqali A, Andersson LI, Jeppsson AD, Abdel-Rehim M
Article Title: Molecularly imprinted polymer-sol-gel tablet toward micro-solid phase extraction: II. Determination of amphetamine in human urine samples by liquid chromatography-tandem mass spectrometry.
Publication date: 2017
Journal: Journal of Chromatography B
Volume: 1063
Page numbers: 130-135.
DOI: 10.1016/j.jchromb.2017.08.027
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1570023217310632

Abstract: Amphetamine selective molecularly imprinted sol-gel polymer tablets, MIP-tablets, for solid-phase microextraction of biofluid samples were prepared. An acetonitrile solution of deuterated amphetamine template and silane precursor, 3-(propylmethacrylate) trimethoxysilane, was soaked into the pores of polyethylene tablet substrates and polymerized by an acid-catalysed sol-gel process. Application of the resultant MIP-tablets to extract amphetamine from human urine samples followed by LC-MS/MS analysis was investigated. The extraction protocol was optimised with respect to pH of sample, addition of sodium chloride, extraction time, desorption solvent and desorption time. The final analysis method determined amphetamine in human urine with a limit of detection (LOD) of 1.0 ng/mL and a lower limit of quantification (LLOQ) of 5 ng/mL. Validation demonstrated accuracy of the method was 91.0-104.0% and inter-assay precision was 4.8-8.5% (RSD). Extraction recovery was 80%. The MIP-tablets could be re-used and the same tablet could be employed for more than twenty extractions
Template and target information: amphetamine
Author keywords: molecularly imprinted polymer, sol-gel, Tablet, Micro-solid phase extraction, amphetamine, urine samples

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