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Reference type: Journal
Authors: Strallhofer AE, Jung S, Jungbauer C, Lieberzeit PA
Article Title: Development of a Novel Platelets Functional Assay Using QCM.
Publication date: 2017
Journal: Proceedings
Volume: 1
Issue: (4)
Page numbers: ArticleNo514.
DOI: 10.3390/proceedings1040514
Alternative URL: http://www.mdpi.com/2504-3900/1/4/514

Abstract: Thrombocytes and their metabolites are involved in numerous physiological and pathophysiological processes, such as blood coagulation at the site of ruptured endothelium. Normal platelet aggregation can be suppressed via platelet antagonists or non-steroidal anti-inflammatory drugs (NSAIDs). That's why differentiating between resting ("normal") and inhibited platelets in a quick and precise fashion could be of a great clinical significance. Herein, we present the first step on the way to a novel platelet functionality assay based on Molecularly Imprinted Polymers (MIP) coated onto Quartz Crystal Microbalance (QCM). First results reveal sensor responses that depend on platelet concentration and on incubation of platelets with aspirin: acetyl salicylic acid (AAS)
Template and target information: platelets, thrombocytes
Author keywords: Molecularly imprinted polymers, MIP, QCM, thrombocytes, acetyl salicylic acid


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