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Reference type: Journal
Authors: Lian WJ, Liang JY, Shen L, Jin Y, Liu HY
Article Title: Enzymatic logic calculation systems based on solid-state electrochemiluminescence and molecularly imprinted polymer film electrodes.
Publication date: 2018
Journal: Biosensors and Bioelectronics
Volume: 100
Page numbers: 326-332.
DOI: 10.1016/j.bios.2017.09.023
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566317306309

Abstract: The molecularly imprinted polymer (MIP) films were electropolymerized on the surface of Au electrodes with luminol and pyrrole (PY) as the two monomers and ampicillin (AM) as the template molecule. The electrochemiluminescence (ECL) intensity peak of polyluminol (PL) of the AM-free MIP films at 0.7V vs Ag/AgCl could be greatly enhanced by AM rebinding. In addition, the ECL signals of the MIP films could also be enhanced by the addition of glucose oxidase (GOD)/glucose and/or ferrocenedicarboxylic acid (Fc(COOH)2) in the testing solution. Moreover, Fc(COOH)2 exhibited cyclic voltammetric (CV) response at the AM-free MIP film electrodes. Based on these results, a binary 3-input/6-output biomolecular logic gate system was established with AM, GOD and Fc(COOH)2 as inputs and the ECL responses at different levels and CV signal as outputs. Some functional non-Boolean logic devices such as an encoder, a decoder and a demultiplexer were also constructed on the same platform. Particularly, on the basis of the same system, a ternary AND logic gate was established. The present work combined MIP film electrodes, the solid-state ECL, and the enzymatic reaction together, and various types of biomolecular logic circuits and devices were developed, which opened a novel avenue to construct more complicated bio-logic gate systems
Template and target information: ampicillin, AM
Author keywords: Biomacromolecular logic gates, Molecularly imprinted polymer films, Electrochemiluminescence, Multi-valued outputs, glucose oxidase

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