MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Zhao CJ, Ma XH, Li JP
Article Title: An Insulin Molecularly Imprinted Electrochemical Sensor Based on Epitope Imprinting.
Publication date: 2017
Journal: Chinese Journal of Analytical Chemistry
Volume: 45
Issue: (9)
Page numbers: 1360-1366.
DOI: 10.1016/S1872-2040(17)61039-9
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1872204017610399

Abstract: A new molecularly imprinted electrochemical sensor for direct detection of insulin was prepared based on epitope imprinting. The molecularly imprinted polymer was fabricated by electropolymerization with C-terminal polypeptide of insulin self-assembled on the Au electrode as template molecule and o-PD as functional monomer. After elution of template molecules by NaOH solution, the imprinting cavities were formed with the three-dimensional structure matching with the C-terminal polypeptide of insulin molecule. The imprinting cavities could specifically recognize and rebind with insulin molecules. With K3[Fe(CN)6]/K4[Fe(CN)6] as a probe, the insulin could be indirectly detected. There was a linear relationship between the response current and the concentration of insulin in the range of 1.0 x 10-14 - 5.0 x 10-13 M, and the detection limit was 7.24 x 10-15 M (3σ/S). The developed sensor exhibited good selectivity and stability; and was successfully applied to determination of insulin in serum samples with satisfactory results
Template and target information: peptide, epitope, C-terminal polypetide of insulin, insulin
Author keywords: Insulin, molecular imprinting, Electrochemical sensor, Epitope imprinting


  Live and Let MIP spoof movie poster bag  Chemistry peptide mug  Chemists are fun customisable shirt

Molecules Special Issue call      Appeal for information






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon