Reference type: Journal
Authors: Liu SC, Liu JX, Pan JM, Luo JL, Niu XH, Zhang T, Qiu FX
Article Title: Two Are Better than One: Halloysite Nanotubes-Supported Surface Imprinted Nanoparticles Using Synergy of Metal Chelating and Low pKa Boronic Acid Monomers for Highly Specific Luteolin Binding under Neutral Condition.
Publication date: 2017
Journal: ACS Applied Materials & Interfaces
Volume: 9
Issue: (38)
Page numbers: 33191-33202.
DOI: 10.1021/acsami.7b11426

Abstract: Surface-imprinted nanoparticles with double recognition (DM-MIPs) are fabricated onto halloysite nanotubes (HNTs) for highly specific separation of natural flavone luteolin (LTL) under neutral condition. Specifically, a two-step strategy via consecutive surface-initiated atom transfer radical polymerization (SI-ATRP) is employed to introduce inherent recognition of molecular imprinting and reversible covalent affinity of boronic acid ligands and immobilized Zn2+ into DM-MIPs. First, Zn2+-immobilized poly(vinyl imidazole) (PVLD) shell based on the HNTs via the first SI-ATRP is prepared to capture LTL by metal chelating. Then HNTs-supported surface imprinted nanoparticles are prepared using low pKa boronic acid monomer 4-(2-acrylamidoethylcarbamoyl)-3-fluorophenylboronic acid (AMC-FPBA) via the second SI-ATRP. Taking advantage of low apparent pKa of AMC-FPBA and large high-affinity binding site density, DM-MIPs possess a promising binding with cis-diol-containing LTL under neutral condition. In static adsorption, DM-MIPs show large LTL loading amount (83.42 mg g-1), fast capture kinetics, remarkable selectivity, and excellent recyclability at pH = 7.0. More importantly, by reducing the pH to 4.0, the loaded TLL can be simply released. As a proof of this concept, a commercially available LTL with 85% purity can be easily enriched and further purified, and the product exhibits the similar antibacterial performance with standard substance
Template and target information: luteolin, LTL
Author keywords: halloysite nanotubes (HNTs), low pKa boronic acid, Luteolin (LTL), metal chelating, specific separation, surface imprinted nanoparticles