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Reference type: Journal
Authors: Sharma PS, Iskierko Z, Noworyta K, Cieplak M, Borowicz P, Lisowski W, D'Souza F, Kutner W
Article Title: Synthesis and application of a "plastic antibody" in electrochemical microfluidic platform for oxytocin determination.
Publication date: 2018
Journal: Biosensors and Bioelectronics
Volume: 100
Page numbers: 251-258.
DOI: 10.1016/j.bios.2017.09.009
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566317306164

Abstract: By means of molecular imprinting of a conducting polymer, molecular cavities selective for oxytocin nonapeptide, an autism biomarker, were designed. Embedding of the oxytocin template, and then its extracting from the molecularly imprinted polymer (MIP) was confirmed by the XPS analysis. AFM imaging of the MIP film surface indicated changes in mechanical properties of the film after template extraction. The MIP synthetic receptor was deposited by potentiodynamic electropolymerization as a thin film on an Au film electrode in an electrochemical miniaturized microfluidic cell. The use of this cell allowed to shorten analysis time and to decrease the sample volume. The linear dynamic concentration range extended from 0.06 to 1 mM with the limit of detection of 60 μM (S/N = 3). Advantageously, sensitivity of the diagnostic microfluidic platform devised for oxytocin determination in both synthetic serum samples and in aqueous solutions was similar and, moreover, it was selective to common interferences, such as oxytocin analogs and potential metabolites
Template and target information: oxytocin, peptide
Author keywords: plastic antibody, Electroactive functional monomer, Microfluidics, Autism biomarker, oxytocin

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