MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Sobiech M, Lulinski P, Halik P, Maciejewska D
Article Title: The selective response of a templated polymer for the cationic drug pentamidine: implications from molecular simulations and experimental data.
Publication date: 2017
Journal: RSC Advances
Volume: 7
Issue: (74)
Page numbers: 46881-46893.
DOI: 10.1039/C7RA07590A

Abstract: In this paper, we present an analysis of the surface modifications responsible for the selectivity of a new imprinted sorbent produced for the isolation of pentamidine cations. We examined the polymers formed from acrylic acid as the monomer, ethylene glycol dimethacrylate as the cross-linker and 4-methoxybenzamidine as the template. A molecular simulation showed the creation of the complex surface system joined with the protonation of the template molecule in a prepolymerization complex. Polymer cavity models enabled the adsorption process to be theoretically simulated, and the binding energies of the structurally related analytes were used as a measure of sorbent selectivity. An applicative analytical scheme for the determination of pentamidine in human urine was used to prove the utility of the templated polymer matrix. The analytical strategy involved separating the pentamidine through a molecularly imprinted solid phase extraction process and detecting it using high-performance liquid chromatography coupled with ultra-violet spectrophotometry. The experimental results demonstrated a good agreement with the theoretical evaluations
Template and target information: pentamidine


  mipdatabase.com logo special offer joke shirt  Lab Chick Periodic table shirt  HE-MAN polymer chemistry shirt

Molecules Special Issue call      Appeal for information






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon