MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Ansari S, Karimi M
Article Title: Synthesis and application of molecularly imprinted polymer for highly selective solid phase extraction trace amount of sotalol from human urine samples: Optimization by central composite design (CCD).
Publication date: 2017
Journal: Medicinal Chemistry Research
Volume: 26
Issue: (10)
Page numbers: 2477-2490.
DOI: 10.1007/s00044-017-1947-1

Abstract: A novel method is described for trace determination of sotalol, a β-blocker drug, using molecularly imprinted solid-phase extraction (MISPE) coupled with high-performance liquid chromatography with UV detection (HPLC/UV). The synthesis of the molecularly imprinted polymer was performed using acrylamide, ethylene glycol dimethacrylate, dimethylformamide, 2,2'-azobisisobutyronitrile and sotalol as a functional monomer, cross-linker monomer, solvent, initiator, and target drug, respectively. Scanning electron microscopy and Fourier transform infrared spectroscopy were used for characterizing the synthesized polymers. Also, a central composite design under response surface methodology and chemometrics applied to investigate and optimize the molecularly imprinted solid-phase extraction procedure parameters such as pH, loading and eluent solvent flow-rate, eluent solvent volume and sorbent mass, that probably influence the extraction process, to achieve the highest sotalol extraction efficiency. Batch rebinding capacity of sotalol was determined from the derived Langmuir isotherm and was found to be 20.08 mg/g. At above specified conditions, the proposed MISPE-HPLC/UV method used for the separation of trace amounts of sotalol in human urine samples with acceptable high recoveries (97-102%) and RSD% lower than 5%. The limit of detection and limit of quantification of the method were 0.01 and 0.04 μg/mL, respectively
Template and target information: sotalol
Author keywords: Sotalol, Central composite design, high performance liquid chromatography, molecularly imprinted polymer, Solid-phase extraction

  I love MIPs hat  multi MIPs logo mug  British periodic table patriotic tote bag

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner