MIPdatabase
Authors: Amjadi M, Jalili R
Article Title: A molecularly imprinted dual-emission carbon dot-quantum dot mesoporous hybrid for ratiometric determination of anti-inflammatory drug celecoxib.
Publication date: 2018
Journal: Spectrochimica Acta Part A-Molecular and Biomolecular Spctroscopy
Volume: 191
Page numbers: 345-351.
DOI: 10.1016/j.saa.2017.10.026
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1386142517308247
Abstract: We report on a ratiometric fluorescent sensor based on dual-emission molecularly imprinted mesoporous silica embedded with carbon dots and CdTe quantum dots (mMIP@CDs/QDs) for celecoxib (CLX) as target molecule. The fluorescence of the embedded CDs is insensitive to the analyte while the green emissive QDs are selectively quenched by it. This effect is much stronger for the MIP than for the non-imprinted polymer, which indicates a good recognition ability of the mesoporous MIP. The hybrid sensor also exhibited good selectivity to CLX over other substances. The ratio of the intensity at two wavelengths (F550/F440) proportionally decreased with the increasing of CLX concentration in the range of 0.08 - 0.90 μM. A detection limit as low as 57 nM was achieved. Experimental results testified that this sensor was highly sensitive and selective for the detection of CLX in human serum samples
Template and target information: celecoxib, CLX
Author keywords: molecularly imprinted polymer, Quantum dots, Carbon dots, Celecoxib, mesoporous silica
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