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Authors: Jalili R, Amjadi M
Article Title: Bio-inspired molecularly imprinted polymer-green emitting carbon dot composite for selective and sensitive detection of 3-nitrotyrosine as a biomarker.
Publication date: 2018
Journal: Sensors and Actuators B: Chemical
Volume: 255
Issue: (Part 1)
Page numbers: 1072-1078.
DOI: 10.1016/j.snb.2017.08.145
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0925400517315745
Abstract: A novel fluorescent sensor was fabricated for 3-nitrotyrosine (3-NT) by using bio-inspired molecularly imprinted polymer as a receptor and green emitting carbon dots (CDs) as a signal transducer. The sensor was simply prepared by immersing CDs in a weak alkaline solution of dopamine containing 3-NT as template. After extracting the embedded template molecules, imprinted binding sites are left in the composite (BMIP@CDs) that selectively recognize the target molecules. The fluorescence intensity of BMIP@CDs is significantly quenched by 3-NT, which forms the basis for its sensitive detection. The sensor was applied for determination of 3-NT in linear concentration range of 0.050-1.85 μM with a detection limit of 17 nM. It exhibited excellent selectivity and a high binding affinity to 3-NT over structurally related compounds and utilized for the detection of 3-NT in spiked human serum samples
Template and target information: 3-nitrotyrosine, 3-NT
Author keywords: molecularly imprinted polymer, Carbon dots, sensor, dopamine, 3-Nitrotyrosine
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