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Reference type: Journal
Authors: Abdallah NA, Ibrahim HF, Hegabe NH
Article Title: Comparative Study of Molecularly Imprinted Polymer and Magnetic Molecular Imprinted Nanoparticles as Recognition Sites for the Potentiometric Determination of Gemifloxacin Mesylate.
Publication date: 2017
Journal: International Journal of Electrochemical Science
Volume: 12
Page numbers: 10894-10910.
DOI: 10.20964/2017.11.74
Alternative URL: http://www.electrochemsci.org/papers/vol12/121110894.pdf

Abstract: Two nanoparticles based potentiometric sensors were fabricated for the selective determination of gemifloxacin mesylate. The first sensor was based on the formation of molecularly imprinted polymer nanoparticles using methacrylic acid as a functional monomer, trimethylolpropane trimethacrylate as a crosslinker and azobisisobutyronitrile as the initiator. The second sensor was based on the use of Fe3O4 magnetic nanoparticles as core shells for the molecularly imprinted polymer. The developed sensors showed high selectivity, stability and sensitivity with wide concentration ranges of 1 x 10-3 - 1 x 10-8 mol L-1 and 1 x 10-3 - 1 x 10-10 mol L-1 for sensors 1 and 2, respectively. They were efficiently applied for the determination of gemifloxacin mesylate in bulk, pharmaceutical tablets and spiked human plasma.
Template and target information: gemifloxacin mesylate
Author keywords: Gemifloxacin, molecularly imprinted, magnetic nanoparticles, carbon paste electrode


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