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Reference type: Journal
Authors: Wang CY, Ye XX, Wang ZG, Wu TS, Wang YY, Li CY
Article Title: Molecularly Imprinted Photo-electrochemical Sensor for Human Epididymis Protein 4 Based on Polymerized Ionic Liquid Hydrogel and Gold Nanoparticle/ZnCdHgSe Quantum Dots Composite Film.
Publication date: 2017
Journal: Analytical Chemistry
Volume: 89
Issue: (22)
Page numbers: 12391-12398.
DOI: 10.1021/acs.analchem.7b03486

Abstract: A novel ionic liquid, 3-{[{4-[((carbamoyl)amino)ethyl methacrylate]butyl} ((carbamoyl)amino)ethyl methacrylate]propyl}-1-ethenyl-1H-imidazol-3-ium bromide (CCPEimBr) functionalized with vinyl, amino, and methacrylate groups, was synthesized and characterized with 1H NMR, FTIR, and HPLC-MS techniques. CCPEimBr was adopted as the functional monomer to prepare a molecularly imprinted polymerized ionic liquid hydrogel film on a glassy carbon electrode surface for human epididymis protein 4 (HE4) sensing. Gold nanoparticles (AuNPs) and ZnCdHgSe QDs were incorporated into the imprinted film as photo-electric active materials. The photocurrent response was measured to investigate the sensing performance of the imprinted sensors toward HE4. The imprinted photo-electrochemical sensor shows excellent selectivity, sensitivity, stability, and accuracy for HE4 determination. Experimental conditions including incubation time and pH value for determining HE4 were optimized in this study. The photocurrent variation (+öI) decreased with increasing HE4 concentration (cHE4), and it was linearly proportional to cHE4 varied from 25 pg mL-1 to 4.0 ng mL-1. The detection limit of the imprinted sensor for determining HE4 was estimated to be 15.4 pg mL-1 (S/N = 3). The imprinted photo-electrochemical sensor was used to determine HE4 in human serum samples accurately
Template and target information: protein, human epididymis protein 4, HE4


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