MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Stepanova MA, Kinziabulatova LR, Nikitina AA, Korzhikova-Vlakh EG, Tennikova TB
Article Title: Cholesterol-imprinted macroporous monoliths: Preparation and characterization.
Publication date: 2017
Journal: Electrophoresis
Volume: 38
Issue: (22-23)
Page numbers: 2965-2974.
DOI: 10.1002/elps.201700335

Abstract: The development of sorbents for selective binding of cholesterol, which is a risk factor for cardiovascular disease, has a great importance for analytical science and medicine. In this work, two series of macroporous cholesterol-imprinted monolithic sorbents differing in the composition of functional monomers (methacrylic acid, butyl methacrylate, 2-hydroxyethyl methacrylate and ethylene dimethacrylate), amount of a template (4, 6 and 8 mol%) used for molecular imprinting, as well as mean pore size were synthesized by in situ free-radical process in stainless steel housing of 50 mm x 4.6 mm i.d. All prepared materials were characterized regarding to their hydrodynamic permeability and porous properties, as well as examined by BET and SEM methods. Imprinting factors, apparent dynamic dissociation constants, the maximum binding capacity, the number of theoretical plates and the height equivalent to a theoretical palate of MIP monoliths at different mobile phase flow rates were determined. The separation of a mixture of structural analogues, namely, cholesterol and prednisolone, was demonstrated. Additionally, the possibility of using the developed monoliths for cholesterol solid-phase extraction from simulated biological solution was shown
Template and target information: cholesterol
Author keywords: affinity binding, artificial receptors, Cholesterol imprinting, Macroporous polymer monoliths, Solid-phase extraction


  mipdatabase.com logo special offer joke shirt  Lab Hunk Periodic shirt    magnet featuring the template Cholesterol

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner