Authors: Krstulja A
, Lettieri S
, Hall AJ
, Roy V
, Favetta P
, Agrofoglio LA
Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine.
Publication date: 2017
Journal: Macromolecular Bioscience
Abstract: Pseudouridine (Y) is an important urinary cancer biomarker, especially in human colorectal cancer (CRC). Disclosed herein is the first Y molecularly imprinted polymer (Y-MIP) material obtained from tailor-engineered functional monomers. The resulting MIP imprint exhibits a remarkable imprinting factor greater than 70. It is successfully used for the selective recognition of Y in spiked human urine. This selective functionalized material opens the route to the development of inexpensive disposable chemosensors for noninvasive CRC diagnosis and prognosis
Template and target information: pseudouridine
Author keywords: cancer, imprinted polymer, molecular recognition, pseudouridine, tailor-made monomer
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