Abstract: In this study, we developed a molecularly imprinted polymer (MIP) that screened platforms to quantify the drug delivery through changes of environment into the blood component. The enhanced surface interactions between the tinplating species and thalidomide were identified by Atomic Force Microscopy as well as force analysis. Overall, the results demonstrate that the approach can affect efficient binding sites through which the MIPs can perform well,clearly indicated distinguishing the different compounds selectively traversed from the whole blood. Detailed examination revealed the surface rearrangements in the presence of the template during polymerization influenced efficient binding sites for (R)-form to penetrate into the protein complex on the RMIP, yet that appeared a substantially marked (S)-form, localized on the SMIP. Therefore the configure biomimesis-MIP approach can be successfully applied for facilitating drug infusion would hold promise for improving of drug delivery.
Template and target information: thalidomide
Author keywords: Molecularly imprinted polymers, multi-step swelling, drug infusion, configuration biomimesis, nanoscience, enhanced surface probe