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Reference type: Journal
Authors: Yoshimi Y, Yagisawa Y, Yamaguchi R, Seki M
Article Title: Blood heparin sensor made from a paste electrode of graphite particles grafted with molecularly imprinted polymer.
Publication date: 2018
Journal: Sensors and Actuators B: Chemical
Volume: 259
Page numbers: 455-462.
DOI: 10.1016/j.snb.2017.12.084
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0925400517324103

Abstract: A real-time heparin monitor could be used to optimize the dosage of heparin during extracorporeal circulation procedures. This report describes the development of a graphite-paste (GP) electrode with molecularly imprinted polymer (MIP) grafted onto it. Heparin-imprinted poly (methacryloxyethyltriammonium chloride -co- acrylamide -co- methylenebisacrylamide) was grafted directly onto graphite particles. The grafted particles were thoroughly mixed with oil to fabricate the MIP-GP electrode. Traditional cyclic voltammetry was performed with the electrode in physiological saline or bovine whole blood containing 5 mM ferrocyanide and 0-8 units/mL heparin. The current intensity increased with heparin concentration, due to expansion of the effective surface area resulting from heparin-promoted mobility of the oil in the MIP-GP electrode. No significant difference was found in the sensitivity of the current to unfractionated heparin among the electrodes fabricated because of the electrode homogenization resulting from thorough mixing of the MIP-grafted particles and oil. (A previous MIP-grafted indium tin oxide electrode exhibited lower sensitivity in blood than in saline.) Only 60 s were needed to stabilize the current. The current at the MIP-GP electrode was also sensitive to low-molecular-weight heparin in blood, but insensitive to chondroitin sulfate C (CSC), which is a heparin analog. The non-imprinted polymer (NIP)-grafted electrode was insensitive to heparin. Thus, the MIP-GP electrode, which operated through a new heparin-sensing mechanism, is an excellent candidate for application as a disposable sensor to monitor heparin levels in blood
Template and target information: heparin
Author keywords: molecularly imprinted polymer (MIP), Heparin, Graphite paste electrode, voltammetry

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