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Reference type: Journal
Authors: Duan DD, Yang H, Ding YP, Ye DX, Li L, Ma GH
Article Title: Three-dimensional molecularly imprinted electrochemical sensor based on Au NPs@Ti-based metal-organic frameworks for ultra-trace detection of bovine serum albumin.
Publication date: 2018
Journal: Electrochimica Acta
Volume: 261
Page numbers: 160-166.
DOI: 10.1016/j.electacta.2017.12.146
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0013468617327202

Abstract: A novel three-dimensional molecularly imprinted electrochemical sensor (MIECS) was fabricated for ultra-trace detection of biomacromolecules bovine serum albumin (BSA), which was based on 3D porous electrocatalytic framework materials (AuNPs@NH2-MIL-125(Ti) composites) and graphene modified glassy carbon electrode. The AuNPs supported amino-functionalized Ti-benzenedicarboxylate porous metal-organic frameworks (Au/NH2-MIL-125(Ti)) was prepared by a simple and rapid ultrasonic method. The stable proteins molecularly imprinted polymers (MIPs) films were fabricated by electropolymerization using l-cysteine (L-Cys) as functional monomers and BSA as templates. The monomer L-Cys interact with AuNPs by AuS bonds and interact with BSA by hydrogen bonding and electrostatic interaction, which was characterized with UV-vis spectra. The morphology of the MIP modified electrode was characterized by scanning electron microscopy, transmission electron microscopy and atomic force microscope. Under the optimal conditions, the 3D MIECS exhibited a wide linear range of 10-18 g mL-1 to 10-12 g mL-1 of BSA and an extremely low detection limit of 4.147 x 10-19 g mL-1. The 3D MIECS has been applied to the assay of BSA in liquid milk samples with satisfying results
Template and target information: protein, bovine serum albumin, BSA
Author keywords: Molecularly imprinted electrochemical sensor, Au nanoparticles, Metal-organic frameworks, Bovine serum albumin, L-cysteine


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