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Reference type: Journal
Authors: Fa SX, Zhao Y
Article Title: Water-Soluble Nanoparticle Receptors Supramolecularly Coded for Acidic Peptides.
Publication date: 2018
Journal: Chemistry - A European Journal
Volume: 24
Issue: (1)
Page numbers: 150-158.
DOI: 10.1002/chem.201703760

Abstract: Sequence-specific recognition of peptides is of enormous importance to many chemical and biological applications, but has been difficult to achieve due to the minute differences in the side chains of amino acids. Acidic peptides are known to play important roles in cell growth and gene expression. In this work, we report molecularly imprinted micelles coded with molecular recognition information for the acidic and hydrophobic side chains of acidic peptides. The imprinted receptors could distinguish acidic amino acids from other polar and nonpolar amino acids, with dissociation constants of tens of nanomolar for biologically active peptides containing up to 18 amino acids
Template and target information: acidic peptides
Author keywords: amino acids, micelles, molecular recognition, nanoparticles, peptides


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