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Abstract: Objective: To establish a method for determination of amantadine residues in chicken by molecularly imprinted-liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Methods: Chicken samples were extracted by 0.1% chloroactic acid and methanol solution (50:50, V:V), and the molecular imprinted polymer chromatography column was purified. Then the amantadine in the extracts were gradient eluted using a gradient elution program of 0.1% formic acid in ammonium solution (A) and methanol solution (B). The quantitative ion and qualitative ion of amantadine were monitored by mass spectrometry with multiple reactions monitoring (MRM). Results: The recoveries of amantadine were ranged from 82.0% to 100.2% at 3 spiked levels of 2, 5 and 10 μg/kg. The relative standard deviations (RSDs) were less than 5.8% (n = 6), and the limit of quantitation (LOQ) for amantadine was 2 μg/kg. Conclusion: The proposed method is rapid, accurate and sensitive, which is suitable for detecting amantadine in chicken samples.
Template and target information: amantadine
Author keywords: Amantadine, High performance liquid chromatography-tandem mass spectrometry, molecularly imprinted polymer, Veterinary drug residues