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Reference type: Journal
Authors: Zhang YZ, Zhang JW, Wang CZ, Zhou LD, Zhang QH, Yuan CS
Article Title: Polydopamine-Coated Magnetic Molecularly Imprinted Polymers with Fragment Template for Identification of Pulsatilla Saponin Metabolites in Rat Feces with UPLC-Q-TOF-MS.
Publication date: 2018
Journal: Journal of Agricultural and Food Chemistry
Volume: 66
Issue: (3)
Page numbers: 653-660.
DOI: 10.1021/acs.jafc.7b05747

Abstract: In this work, a modified pretreatment method using magnetic molecularly imprinted polymers (MMIPs) was successfully applied to study the metabolites of an important botanical with ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). The MMIPs for glucoside-specific adsorption was used to identify metabolites of Pulsatilla chinensis in rat feces. Polymers were prepared by using Fe3O4 nanoparticles as the supporting matrix, d-glucose as fragment template, and dopamine as the functional monomer and cross-linker. Results showed that MMIPs exhibited excellent extraction performance, large adsorption capacity (5.65 mg/g), fast kinetics (60 min), and magnetic separation. Furthermore, the MMIPs coupled with UPLC-Q-TOF-MS were successfully utilized for the identification of 17 compounds including 15 metabolites from the Pulsatilla saponin metabolic pool. This study provides a reliable protocol for the separation and identification of saponin metabolites in a complex biological sample, including those from herbal medicines
Template and target information: fragment template, d-glucose, glucosides
Author keywords: fragment template, Magnetic molecularly imprinted polymers, Metabolites study, P.chinensis

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