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Reference type: Journal
Authors: Hirayama M, Tsuruta K, Kawamura A, Ohara M, Shoji K, Kawano R, Miyata T
Article Title: Design of protein-responsive micro-sized hydrogels for self-regulating microfluidic systems.
Publication date: 2018
Journal: Journal of Micromechanics and Microengineering
Volume: 28
Issue: (3)
Page numbers: ArticleNo034002.
Alternative URL: http://stacks.iop.org/0960-1317/28/i=3/a=034002

Abstract: Diagnosis sensors using micro-total analysis systems ( μ-TAS) have been developed for detecting target biomolecules such as proteins and saccharides because they are signal biomolecules for monitoring body conditions and diseases. In this study, biomolecularly stimuli-responsive micro-sized hydrogels that exhibited quick shrinkage in response to lectin concanavalinA (ConA) were prepared in a microchannel by photopolymerization using a fluorescence microscope. In preparing the micro-size hydrogels, glycosyloxyethyl methacrylate (GEMA) as a ligand monomer was copolymerized with a crosslinker in the presence of template ConA in molecular imprinting. The ConA-imprinted micro-hydrogel showed greater shrinkage in response to target ConA than nonimprinted micro-hydrogel. When a buffer solution was switched to an aqueous ConA solution in the Y-shaped microchannel, the flow rates changed quickly because of the responsive shrinkage of the micro-hydrogel prepared in the microchannel. These results suggest that the ConA-imprinted micro-hydrogel acted as a self-regulated microvalve in microfluidic systems
Template and target information: protein, lectin, concanavalin A, ConA

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