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Reference type: Journal
Authors: Yang F, Wang RR, Na GS, Yan QL, Lin ZS, Zhang ZF
Article Title: Preparation and application of a molecularly imprinted monolith for specific recognition of domoic acid.
Publication date: 2018
Journal: Analytical and Bioanalytical Chemistry
Volume: 410
Issue: (6)
Page numbers: 1845-1854.
DOI: 10.1007/s00216-017-0843-3

Abstract: In this work, a molecularly imprinted monolithic column was synthesized by a facile procedure and was applied for specific recognition of domoic acid, an amnesic shellfish poison. The poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) molecularly imprinted monolith was synthesized in a stainless steel column by in situ polymerization. Pentane-1,3,5-tricarboxylic acid was used as a dummy imprinting template instead of the highly toxic and expensive target molecule. It is the first time that a molecularly imprinted monolith is introduced-for separation and detection of domoic acid. After optimizing the preparation conditions, the prepared imprinted monolith was systematically characterized and exhibited excellent stability and permeability as a HPLC stationary phase. The results of chromatographic analysis demonstrated that the molecularly imprinted monolith exhibited specific retention and selective recognition toward domoic acid, with-an imprinted factor up to 3.77. Furthermore, the molecularly imprinted monolith was successfully applied for selective enrichment of domoic acid from biological samples
Template and target information: pentane-1,3,5-tricarboxylic acid, dummy template, domoic acid
Author keywords: molecular imprinting, monolith, Domoic acid, high performance liquid chromatography

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