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Abstract: Sulfamethazine and sulfamethoxazole are anti-bacterial and anti-infective agents. Molecular imprinted polymers of these agents were prepared by the technique of non-covalent molecular imprinting polymerization. The functional monomers used include methacrylic acid, 4-vinylpyridine, acrylamide or a combination of methacrylic acid and 4-vinylpyridine. The polymers obtained were packed in a high-performance liquid chromatography (HPLC) column, and the molecular recognition mechanism regulating the binding behavior was studied using chromatography. The results showed that methacrylic acid was suitable for synthesizing sulfamethazine-selective polymer, whereas 4-vinylpyridine was suitable for sulfamethoxazole. Although these two compounds have similar structures, the interactions between them and the monomers are different. The selective polymers are expected to be of use for analyzing sulfonamide compounds in the food industry and clinic applications. (C) 2001 Elsevier Science B.V. All rights reserved