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Reference type: Journal
Authors: Hu LQ, Zhou TT, Feng JW, Jin H, Tao Y, Luo D, Mei SR, Lee YI
Article Title: A rapid and sensitive molecularly imprinted electrochemiluminescence sensor for Azithromycin determination in biological samples.
Publication date: 2018
Journal: Journal of Electroanalytical Chemistry
Volume: 813
Page numbers: 1-8.
DOI: 10.1016/j.jelechem.2018.02.010
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1572665718300948

Abstract: Azithromycin (AZM) is a widely used macrolide antibiotic to treat infections caused by bacteria. Considering the side-effect to human health, a rapid and selective electrochemiluminescence (ECL) sensor was fabricated on the basis of molecularly imprinted polymer (MIP) modified carbon paste electrode as a recognition element. We systematically optimized the factors influencing the processes on the extraction and determination for AZM, including the amount of MIP power and paraffin oil, extraction solution, extraction time and the pH of Ru(bpy)32+ solution. Under the optimal condition, the wide linear range was observed from 1.0 x 10-10 to 4.0 x 10-7 mol L-1, and the limit of detection (LOD) was low as 2.3 x 10-11 mol L-1 (S/N = 3). The spiked recoveries of AZM in urine and blood samples were from 98.4% to 113.5% with RSD changing from 3.7% to 13.2%, respectively. The results of AZM determination by this proposed sensor were in accordance with that of high-performance liquid chromatographyG«Űtandem mass spectrometry method. Thus, the developed MIP-based ECL sensor will have a great potential application in rapid and sensitive determination of trace AZM in complex biological samples
Template and target information: azithromycin, AZM
Author keywords: Azithromycin, Electrochemiluminescence sensor, molecularly imprinted polymer, biological samples


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