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Abstract: In the present research, design and construction of a development potentiometric sensor based on a newly nanosensing layer for the sensitive determination of tramadol in various real samples were suggested. The proposed nanosensing layer was fabricated with the incorporation of a synthesized tramadol-imprinted polymer nanoparticles "as an efficient sensing agent" into the carbon paste matrix composed of graphite powder, decorated graphene nanosheets with silver nanoparticles, and a typically ionic liquid as the conductive pasting binder. The detection limit and the linear range of this study were found to be 2.04 x 10-9 and 3.50 x 10-9 to 1.00 x 10-2 M with a Nernstian slope of 59.85 ± 0.13 mV decade-1, respectively. The presented modified carbon paste sensor was successfully applied for the determination of tramadol in pharmaceutical and biological samples
Template and target information: tramadol
Author keywords: Tramadol-imprinted polymer, potentiometric sensor, Decorated nanographene, Silver nanoparticles, Ionic liquid