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Reference type: Journal
Authors: Zhou J, He XW, Zhao J, Shi HM
Article Title: A study of binding action and selectivity of trimethoprim molecular template polymer.
Publication date: 1999
Journal: Chemical Journal of Chinese Universities
Volume: 20
Issue: (2)
Page numbers: 204-208.
Alternative URL: http://en.cnki.com.cn/Article_en/CJFDTotal-GDXH902.009.htm

Abstract: A molecularly templated synthetic polymer receptor highly selective for trimethoprim was prepared by a molecular sell-assembly imprinting technique. The selective binding characteristics of the template polymer were evaluated by Scatchard analysis, H-1 NMR study and Ultraviolet spectrometry. The results showed that a class of same binding sites, which could specifically bind to trimethoprim by cooperative hydrogen bonding, were formed in the polymer, and its dissociation constant was estimated to be 2.22 x 10(-4) mol/L, The selective binding experiments for substrates indicated that the polymer gave much higher affinity and selectivity for trimethoprim than for sulfanilamide and sulfapyridine. It is possible to be a good adsorption and binding material in the selective enrichment and determination of trace trimethoprim in complex biosamples
Template and target information: trimethoprim


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